Amlexanox
Therapeutic Class: Drugs for aphthous ulcer
Indications:
Amlexanox is indicated for the treatment of aphthous ulcers in people with a normal system.
Description:
The mechanism of action by which Amlexanox accelerates the healing of aphthous ulcers is unknown. In vitro studies have demonstrated Amlexanox to be a potent inhibitor of the formation and release of inflammatory mediators (histamine and leukotrienes) from mast cells, neutrophils, and mononuclear cells. Given orally to animals, Amlexanox has demonstrated anti-allergic and anti-inflammatory activities and has been shown to suppress both immediate and delayed-type hypersensitivity reactions. The relevance of those activities of Amlexanox to its effects on aphthous ulcers has not been established.
Dosage & Administration:
Adults (over 18 years of age): Apply the paste as soon as possible after noticing the symptoms of an ulcer. still use the paste fourfold daily, preferably following oral hygiene after breakfast, lunch, dinner, and at bedtime. Dry the ulcer(s) by gently patting it with a soft, clean cloth. Wash hands before applying. Moisten the tip of the index & squeeze a dab of paste approximately ¼ inch (0.5 cm) onto the fingertip. Gently dab the paste onto every ulcer. Repeat the method if quite one ulcer is present. Wash hands after application. Use the paste until the ulcer heals. If significant healing or pain relief has not occurred in 10 days, consultation with the physician is required.
Contraindications:
Amlexanox oral paste is contraindicated in patients with known hypersensitivity to Amlexanox or other ingredients within the formulation.
Side Effects:
The most common side effects are transient pain, stinging, and/or burning at the location of the application. The less frequent side effects are contact mucositis, nausea, and diarrhea.
Pregnancy & Lactation:
Pregnancy category B. No adverse fetal effects were observed during teratological studies on animals, but there are not any adequate and well-controlled studies in pregnant women. So this drug should be used during pregnancy as long as clearly needed.
Lactation: Amlexanox was found within the milk of lactating rats; therefore, caution should be exercised when administering Amlexanox oral paste to a nursing woman.
Precautions & Warnings:
Wash hands immediately after applying Amlexanox oral paste onto ulcers with the fingertips. Wash eyes promptly if they ought to are available in contact with the paste. within the event that a rash or contact mucositis occurs, discontinue use.
Overdose:
Ingestion of a full tube would end in systemic exposure below the utmost nontoxic dose of Amlexanox in animals. Gastrointestinal upset like diarrhea and vomiting could result from an overdose.
Storage:
Store in a cool & dry place. Protect from light. exclude of reach of the children.