Betamethasone + Salicylic Acid
Therapeutic Class: Topical anti-inflammatory preparations
Indications:
Betamethasone & Salicylic Acid Scalp lotion or ointment is indicated for the relief of inflammatory manifestations of psoriasis and seborrhea of the scalp. This scalp lotion or ointment is also indicated for the relief of inflammatory manifestations of non-scalp lesions of psoriasis and other corticosteroid-responsive dermatoses.Pharmacology:
Betamethasone may be a glucocorticoid receptor agonist. This results in changes in genetic expression once this complex binds to the GRE. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition of arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The system is suppressed by corticosteroids thanks to a decrease within the function of the systema lymphaticum, a discount in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Betamethasone binds to plasma transcortin, and it becomes active when it's not sure to transcortin.
Salicylic acid directly and irreversibly inhibits the activity of both sorts of cyclo-oxygenases (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. Salicylate may competitively inhibit prostaglandin formation. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms. 2-hydroxybenzoic acid may be a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis, and warts. It works by causing the cells of the epidermis to slough off more readily, preventing pores from clogging up, and allowing room for brand spanking new cell growth. due to its effect on skin cells, 2-hydroxybenzoic acid is employed in several shampoos wont to treat dandruff.
Dosage & Administration:
Apply a few drops of Betamethasone & 2-hydroxybenzoic acid Scalp lotion or ointment to the affected area and massage gently and thoroughly onto the scalp or skin. the standard frequency of application is twice daily, within the morning and in the dark.
Contraindications:
Betamethasone & 2-hydroxybenzoic acid Scalp lotion or ointment is contraindicated in those patients with a history of sensitivity reactions to any of its components.
Side Effects:
Side effects that are reported with the appliance of topical corticosteroids include burning, itching, irritation, dryness, folliculitis, hypertrichosis, hypopigmentation, perioral dermatitis, and allergic dermatitis. 2-hydroxybenzoic acid preparations may cause dermatitis.
Pregnancy & Lactation:
The safety of this medicine during pregnancy and breastfeeding has not been established. However, topical steroids shouldn't be used extensively in pregnancy i.e. in large amounts or for protracted periods.
Precautions & Warnings:
If irritation or sensitization develops with the utilization of Betamesal Scalp lotion or ointment, treatment should be discontinued. Systemic absorption of topical corticosteroids or 2-hydroxybenzoic acid could also be increased if extensive body surface areas are treated. The application of 2-hydroxybenzoic acid to open wounds or damaged skin should be avoided.
Overdose Effects:
Overdose of topical corticosteroids can suppress pituitary-adrenal functions leading to secondary adrenal insufficiency and produce manifestations of hypercorticism, including Cushing's disease. With topical preparations containing 2-hydroxybenzoic acid, the overdose of it's going to end in symptoms of salicylic.
Storage:
Store in a cool & dry place, protected from light and keep out of the reach of children.