Generic Name বাংলায় দেখুন
Cefixime TrihydrateTherapeutic Class: Third Generation Cephalosporins
Indications:
Cefixime is indicated within the treatment of the subsequent infections once caused by the prone strains of the selected microorganisms:
Cefixime is indicated within the treatment of the subsequent infections once caused by the prone strains of the selected microorganisms:
- Uncomplicated tract infections caused by E. coli and Proteus Mirabilis.
- Otitis Media is caused by Haemophilus influenzae, Moraxella catarrhalis, and streptococci pyogenes.
- Pharyngitis and rubor are caused by streptococci pyogenes.
- Acute respiratory disease and acute exacerbations of bronchitis caused by streptococci pneumonia and Haemophilus influenza.
- Uncomplicated Cupid's itch (cervical/urethral) caused by gonococcus.
Description:
Cefixime could be a third-generation synthetic antibiotic drug antibiotic for oral administration. it's a disinfectant against a broad spectrum of gram-positive and gram-negative microorganisms at simply realizable plasma concentrations. It kills microorganisms by being busy within the synthesis of microorganism semipermeable membrane. it's extremely stable within the presence of a penicillinase accelerator. As a result, several organisms immune to penicillins and a few cephalosporins thanks to the presence of beta-lactamases, are also prone to Cefixime. Absorption of it's regarding four-hundredth to five hundredths whether or not administered with or while not food.
Dosage & Administration:
The usual course of treatment is seven days. this might be continued for up to fourteen days reckoning on the severity of the infection.
Cefixime could be a third-generation synthetic antibiotic drug antibiotic for oral administration. it's a disinfectant against a broad spectrum of gram-positive and gram-negative microorganisms at simply realizable plasma concentrations. It kills microorganisms by being busy within the synthesis of microorganism semipermeable membrane. it's extremely stable within the presence of a penicillinase accelerator. As a result, several organisms immune to penicillins and a few cephalosporins thanks to the presence of beta-lactamases, are also prone to Cefixime. Absorption of it's regarding four-hundredth to five hundredths whether or not administered with or while not food.
Dosage & Administration:
The usual course of treatment is seven days. this might be continued for up to fourteen days reckoning on the severity of the infection.
Adult and youngsters over twelve years: The suggested adult dose is a pair of00-400 mg (1 to 2 capsules) daily, given either as one dose or in 2 divided doses. For the treatment of uncomplicated cervical/urethral gonococcal infections, one oral dose of Cefixime four hundred mg is suggested.
Children (6 months or older): sometimes eight mg/kg/day given as one dose or in 2 divided doses or is also given as following
Interaction:
Carbamazepine: Concomitant use elevates the carbamazepine level. anticoagulant and different anticoagulants: Concomitant use will increase clotting factor time.
Contraindications:
It is contraindicated in hypersensitivity to Cefixime or different cephalosporins.
Side Effects:
The drug is mostly well tolerated. the foremost frequent aspect effects area unit symptom and stool changes; that is a lot of ordinarily related to higher doses. different aspect effects area unit nausea, abdominal pain, dyspepsia, vomiting, flatulence, headache, and lightheadedness. Allergies within the type of rash, pruritus, urticaria, drug fever, and hurting are reportable. These reactions sometimes subsided upon discontinuation of medical aid.
Pregnancy & Lactation:
There are, however, no adequate and well-controlled studies in pregnant ladies. as a result of animal, copy studies don't seem to be forever prophetical of human response, this drug ought to be used throughout physiological conditions as long as clearly required. it's not identified that Cefixime is excreted in human milk. So, caution ought to be exercised once Cefixime is run to a nursing lady.
Precautions & Warnings:
The drug ought to be prescribed with caution in people with a history of channel malady, significantly inflammatory bowel disease. The drug ought to be with caution in patients with marked impaired excretory organ operation moreover as those undergoing continuous ambulant serous membrane chemical analysis and dialysis. dose adjustment is simply necessary in severe kidney disease (creatinine clearance < twenty ml/min), therein case a dose of two hundred mg once daily mustn't be exceeded.
Overdose :
Gastric Lavage is also indicated; otherwise, no specific remedy exists. Cefixime isn't removed in vital quantities from the circulation by dialysis or serous membrane chemical analysis. Adverse reactions in little numbers of healthy adult volunteers receiving single doses up to a pair of g of Cefixime didn't dissent from the profile seen in patients treated at the suggested doses.
Storage :
Keep below 30ºC temperature, shielded from light-weight & wet. shut off the reach of kids.
- ½-1 year: seventy-five mg daily.
- 1-4 years: a hundred mg daily.
- 5-10 years: two hundred mg daily.
- 11-12 years: three hundred mg daily
- In typhoid, the dose ought to be ten mg/kg/day for fourteen days.
Interaction:
Carbamazepine: Concomitant use elevates the carbamazepine level. anticoagulant and different anticoagulants: Concomitant use will increase clotting factor time.
Contraindications:
It is contraindicated in hypersensitivity to Cefixime or different cephalosporins.
Side Effects:
The drug is mostly well tolerated. the foremost frequent aspect effects area unit symptom and stool changes; that is a lot of ordinarily related to higher doses. different aspect effects area unit nausea, abdominal pain, dyspepsia, vomiting, flatulence, headache, and lightheadedness. Allergies within the type of rash, pruritus, urticaria, drug fever, and hurting are reportable. These reactions sometimes subsided upon discontinuation of medical aid.
Pregnancy & Lactation:
There are, however, no adequate and well-controlled studies in pregnant ladies. as a result of animal, copy studies don't seem to be forever prophetical of human response, this drug ought to be used throughout physiological conditions as long as clearly required. it's not identified that Cefixime is excreted in human milk. So, caution ought to be exercised once Cefixime is run to a nursing lady.
Precautions & Warnings:
The drug ought to be prescribed with caution in people with a history of channel malady, significantly inflammatory bowel disease. The drug ought to be with caution in patients with marked impaired excretory organ operation moreover as those undergoing continuous ambulant serous membrane chemical analysis and dialysis. dose adjustment is simply necessary in severe kidney disease (creatinine clearance < twenty ml/min), therein case a dose of two hundred mg once daily mustn't be exceeded.
Overdose :
Gastric Lavage is also indicated; otherwise, no specific remedy exists. Cefixime isn't removed in vital quantities from the circulation by dialysis or serous membrane chemical analysis. Adverse reactions in little numbers of healthy adult volunteers receiving single doses up to a pair of g of Cefixime didn't dissent from the profile seen in patients treated at the suggested doses.
Storage :
Keep below 30ºC temperature, shielded from light-weight & wet. shut off the reach of kids.
Brand Names
Brand Name | Company | Strength |
| Afix | Aristopharma Ltd. | 200 mg+400 mg |
| Triocim | Beximco Pharmaceuticals Ltd. | 200 mg+400 mg |
| Emixef | Incepta Pharmaceuticals Ltd. | 200 mg+400 mg |
| Cef-3 | Square Pharmaceuticals Ltd. | 200 mg+400 mg |
| Ceftid | Opsonin Pharma Ltd. | 200 mg+400 mg |
| Cexime | GlaxoSmithKline | 200 mg+400 mg |