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Generic Name                                                 বাংলায় দেখুন

Cefuroxime Axetil

Therapeutic Class: Antimicrobial drugs (Second-generation Cephalosporins)

Indications:

It is indicated for the treatment of infections caused by sensitive bacteria.

• Pharyngitis/Tonsillitis caused by Streptococcus pyogenes.
• Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (beta-lactamase-producing strains), or Streptococcus pyogenes.
• Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae (non-beta-lactamase producing strains)
• Lower respiratory tract infections including pneumoniae, caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta-lactamase-producing strains), Klebsiella spp., Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains), Streptococcus pyogenes, E. coli
• Acute bacterial exacerbation of chronic bronchitis and Secondary bacterial infections of acute bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae (beta-lactamase negative strains), or Haemophilus parainfluenzae (beta-lactamase negative strains).
• Skin and skin structure infections are caused by Staphylococcus aureus (including beta-lactamase-producing strains) or Streptococcus pyogenes.
• Urinary tract infections are caused by E.coli or Klebsiella pneumoniae.
• Bone and Joint Infections caused by Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains).
• Gonorrhea is caused by penicillinase-producing and non-penicillinase-producing strains of Neisseria gonorrhoeae.
• Early Lyme Disease (erythema migrans) is caused by Borrelia burgdorferi.

Description:

Cefuroxime may be a well-characterized and effective bactericide agent, that has broad-spectrum antiseptic activity against a good vary of common pathogens, as well as manufacturing strains. Mefoxin has smart stability to microorganisms and consequently, is active against several ampicillin-resistant and Amoxycillin-resistant strains.

Dosage & Administration:

Tablet or Suspension-
Adolescents and adults (13 years and older)-

• Pharyngitis/tonsillitis: 250 mg b.i.d. for 5-10 days
• Acute microorganism jaw sinusitis: 250 mg b.i.d. for ten days
• Acute microorganism exacerbation of chronic bronchitis: 250-500 mg b.i.d. for ten days
• Secondary microorganism infections of acute bronchitis: 250-500 mg b.i.d. for 5-10 days
• Uncomplicated skin and skin structure infections: 250-500 mg b.i.d. for ten days
• Uncomplicated tract infections: 250 mg b.i.d. for 7-10 days
• Uncomplicated Gonorrhoea: one thousand mg Single dose
• Community nonheritable pneumonia: 250-500 mg b.i.d. for 5-10 days
• MDR enteric fever Fever: five hundred mg b.i.d. for 10-14 days
• Early Lyme disease: five hundred mg b.i.d. for twenty days

Pediatric Patients (3 months to 12 years)-

• Pharyngitis/Tonsillitis: twenty mg/kg/day b.i.d for 5-10 days
• Acute redness media: thirty mg/kg/day b.i.d for ten days
• Acute microorganism jaw sinusitis: thirty mg/kg/day b.i.d for ten days
• Impetigo: thirty mg/kg/day b.i.d for ten-day

Parenteral-

• Adult: 750 mg thrice daily by IM or IV injection. In severe infections, doses are often increased up to one.5 metric weight units thrice daily by IV injection. The frequency could also be increased to fourfold daily, if necessary, giving total daily doses of three to six gms.
• Children (above three months of age): thirty - a hundred mg/kg/day given in three or four equally divided doses. A dose of sixty mg/kg/day is suitable for many infections.
• Neonate: thirty - a hundred mg/kg/day given in a pair of or three equally divided doses.
• Surgical prophylaxis: one.5 metric weight unit by IV injection at induction of anesthesia; up to three doses of 750 mg could also be given by IV/IM injection every eight hours for top risk procedures.
• Pneumonia: one.5 metric weight unit IV injection double daily for 2-3 days, followed by five hundred mg double daily (oral) for 7-10 days.
• Acute exacerbations of chronic bronchitis: 750 mg double daily (IM or IV injection) for 2-3 days, followed by five hundred mg double daily (oral) for 5-10 days. (Duration of each channel and oral medical aid is set by the severity of the infection and also the clinical standing of the patient.)
• In Gonorrhoea: Adult: one.5 metric weight unit as one dose (as a pair of x 750mg injections intramuscularly with totally different sites, e.g. every buttock).

In Meningitis:

• Adult: three metric weight unit IV injection thrice daily.
• Children (above three months of age): 200-240 mg/kg/day by IV injection in three or four divided doses reduced to a hundred mg/kg/day once three days or on clinical improvement.
• Neonate: a hundred mg/kg/day by IV injection at initial dose, reduced to fifty mg/kg/day, once clinically indicated. 

In bone and joint infections:

• Adult: 1.5 metric weight unit IV injection fourfold daily.
• Children (above three months of age): a hundred and fifty mg/kg/day (not to exceed the utmost adult dose) in equally divided doses every eight hours.

Administration: The use of freshly reconstituted resolution is usually recommended. However, it maintains efficiency for a minimum of twenty-four hours at temperature or forty-eight hours at 5o C

Interaction:

No, doubtless risky interactions are according.

Contraindications:

Cefuroxime is contraindicated in patients with acknowledged hypersensitivity reaction to Cephalosporins.

Side Effects:

Adverse effects to Mefoxin have occurred sometimes and are typically gentle and transient in nature. Effects according to embrace rashes and channel disturbances. like different antibiotics, prolonged use could lead to the overgrowth of non-inclined organisms e.g. Candida.

Pregnancy & Lactation:

US office physiological state class of Mefoxin is B. There are, however, no adequate and well-controlled studies in pregnant girls. as a result of animal, replica studies aren't invariably prophetic of human response, this drug ought to be used throughout the physiological state given that clearly required. Mefoxin is shown to be excreted in human milk. So, caution ought to be exercised once Mefoxin is run to a nursing lady.

Precautions & Warnings: 

Cefuroxime ought to tend with care to patients receiving coincident treatment with potent diuretics & the UN agency has a history of inflammatory bowel disease. Mefoxin antibiotics could generally tend safely to patients UN agency area unit allergic to antibiotic drug though cross-reactions have according. Mefoxin has shown, that's unlikely to be a drag at the suggested dose levels.

Reconstitution:
For 750 mg contractor injection: Add three-milliliter water for injection to ampoule so shake gently for dispersion.
For 750 mg blood vessel injection: Add eight-milliliter water for injection to ampoule so shake gently for dispersion. the answer ought to be slowly injected directly into a vein over a three to five minutes amount.
For 1.5 g blood vessel injection: Add sixteen milliliter Water for injection to ampoule so shake gently for dispersion. the answer ought to be slowly injected directly into a vein over a three to five minutes amount.

Storage :

Store in a very cool, dry place (below 30o C), aloof from light-weight & wet. keep of the reach of kids.

Brand Names

Brand Name	Company	Strength
Axim	Aristopharma Ltd.	250 mg+500 mg+125 mg/5 ml 750 mg/vial,1.5 gm/vial
Turbocef	Beximco Pharmaceuticals Ltd.	250 mg+500 mg+125 mg/5 ml 750 mg/vial,1.5 gm/vial
Kilbac	Incepta Pharmaceuticals Ltd.	250 mg+500 mg+125 mg/5 ml 750 mg/vial,1.5 gm/vial
Cefotil	Square Pharmaceuticals Ltd.	250 mg+500 mg+125 mg/5 ml 750 mg/vial,1.5 gm/vial
Sefur	Opsonin Pharma Ltd.	250 mg+500 mg+125 mg/5 ml 750 mg/vial,1.5 gm/vial
Cefobac	Popular Pharmaceuticals Ltd.	250 mg+500 mg+125 mg/5 ml 750 mg/vial,1.5 gm/vial