Therapeutic Class: 4-Quinolone preparations, Anti-diarrhoeal Antimicrobial medicine
Pharmacology:
Ciprofloxacin is also an artificial fluoroquinolone. it's disinfectant activity against an honest vary of gram-positive and gram-negative organisms. It inhibits microorganism desoxyribonucleic acid synthesis by binding with the microorganism enzyme-DNA gyrase and topoisomerase IV that a square measure to blame for desoxyribonucleic acid supercoiling.
Indications:
Ciprofloxacin is indicated for the treatment of tract Infections, Urinary tract infections, girdle Inflammatory Diseases, Infectious symptoms (Shigella dysenteriae, vibrion cholera), typhoid, Intra-abdominal infections, inflammation, Skin, and Soft Tissue Infections, Bone and Joint Infections, Gonorrhea, Neutropenic patients with fever because of microorganism infection, Meningitis, Surgical bar.
Dosage:
Tablet:
Adult:
10-20 mg/kg (max. 750 mg) doubly daily (10 to twenty-one days). The length of medical aid depends on the type and severity of the infection.
Extended unharness tablet: In uncomplicated tract infection (acute cystitis), the suggested dose of extended unharness pill is one thousand mg pill once daily for three days.
For IV infusion:
Instruction for the use of Cipro IV infusion-
Interaction:
Concurrent administration of Cipro ought to be avoided with metal or metal-containing antacids or medicament or with a different product containing metallic element, Iron, or metal. This product might even be taken 2 hours once or six hours before Cipro. Cipro should not be taken at the same time with milk or different dairy farm product, since absorption of Cipro might even be considerably reduced. The dietary metallic element is also a vicinity of a meal, however, does not considerably have an effect on the absorption of Cipro.
Contraindications:
It is contraindicated in patients World Health Organization has famous hypersensitivity to Cipro or different quinolones.
Side Effects:
Side effects include- nausea and different gi disturbances, headache, dizziness, joint pain, and skin rashes.
Pregnancy & Lactation:
There don't seem to be adequate and well-controlled studies in pregnant ladies. Cipro ought to be used throughout gestation as long because the potential profit justifies the potential risk to the vertebrate and mother. Cipro is excreted in human milk. because of the potential risk of articulary injury, Cipro should not be used throughout lactation.
Precautions & Warnings:
Patients receiving Cipro ought to be schooled to drink fluids munificently. It ought to be used with caution in patients with suspected or famous system disorders like encephalopathy or different factors that incline to seizures and convulsion. Avoid in patients with famous QT prolongation, symptoms.
Use in Special Populations:
Although effective in clinical trials, Cipro is not a drug of initial alternative in the pediatric population.
Overdose :
Overdose following Cipro administration might cause seizures, hallucinations, confusion, abdominal discomfort, urinary organ, and viscus impairment conjointly as crystalluria, haematuria, & reversible urinary organ toxicity.
Storage:
Keep below 30°C temperature, protected from lightweight & wetness. exclude of the reach of kids.
- Respiratory Tract Infections: 500 to 750 mg doubly daily (7 to fourteen days)
- Urinary tract infections: 250 to 750 mg doubly daily (3 to ten days)
- Pelvic Inflammatory Diseases: 500 to 750 mg doubly daily (14 days)
- Infectious symptom (Shigella dysenteriae, vibrion cholera): five hundred mg doubly daily (1 to 5 days)
- Typhoid fever: 500 mg doubly daily (7 days)
- Intra-abdominal infections: 500 to 750 mg doubly daily (5 to fourteen days)
- Prostatitis: five hundred to 750 mg doubly daily (2 to 6 weeks)
- Skin and Soft Tissue Infections: 500 to 750 mg doubly daily (7 to fourteen days)
- Bone and Joint Infections: 500 to 750 mg doubly daily (max. 3 months)
- Gonorrhea: 500 mg united dose
- Neutropenic patients with fever because of microorganism infection: 500 to 750 mg doubly daily co-administered with acceptable antibacterials.
- Meningitis: 500 mg united dose.
- Surgical prophylaxis: 500 mg united dose, an hour before the procedure.
10-20 mg/kg (max. 750 mg) doubly daily (10 to twenty-one days). The length of medical aid depends on the type and severity of the infection.
Extended unharness tablet: In uncomplicated tract infection (acute cystitis), the suggested dose of extended unharness pill is one thousand mg pill once daily for three days.
For IV infusion:
- Urinary Tract Infection: delicate to Moderate: two hundred mg twelve hourly for 7-14 days; Severe or Complicated: four hundred mg twelve hourly for 7-14 days
- Lower tract infection: delicate to Moderate: four hundred mg twelve hourly for 7-14 days; Severe or Complicated: four hundred mg eight hourly for 7-14 days
- Nosocomial Pneumonia: Mild/Moderate/Severe: four hundred mg eight hourly for 10-14 days
- Skin and Skin Structure: delicate to Moderate: four hundred mg twelve hourly for 7-14 days; Severe or Complicated: four hundred mg eight hourly for 7-14 days
- Bone and Joint Infection: delicate to Moderate: four hundred mg twelve hourly for quite 4-6 weeks; Severe/Complicated: four hundred mg eight hourly for quite 4-6weeks
- Intraabdominal (Acute abdomen): Complicated: four hundred mg twelve hourly for 7-14 days
- Acute Sinusitis: Mild/Moderate: four hundred mg twelve hourly for ten days
- Chronic microorganism Prostatitis: Mild/Moderate: four hundred mg twelve hourly for twenty-eight Days.
Instruction for the use of Cipro IV infusion-
- Check the bag for minute leaks by squeeze the inner bag firmly. If leaks square measure found, or if seal is not intact, discard the solution.
- Insert piercing pin of administration set into port with a twisting motion till the pin is firmly sitting.
- Suspend bag from the hanger.
- Squeeze and unharness drip chamber to work out correct fluid level in the chamber throughout the infusion of Cipro IV infusion.
- Do not use if the solution is cloudy or a precipitate is a gift.
- Do not use versatile baggage serial connections.
- Close flow management clamp of administration set.
- Remove cowl from the port inside of the bag.
- Open flow management clamp to expel air from set.Close clamp.
- Regulate rate of administration with flow management clamp
Interaction:
Concurrent administration of Cipro ought to be avoided with metal or metal-containing antacids or medicament or with a different product containing metallic element, Iron, or metal. This product might even be taken 2 hours once or six hours before Cipro. Cipro should not be taken at the same time with milk or different dairy farm product, since absorption of Cipro might even be considerably reduced. The dietary metallic element is also a vicinity of a meal, however, does not considerably have an effect on the absorption of Cipro.
Contraindications:
It is contraindicated in patients World Health Organization has famous hypersensitivity to Cipro or different quinolones.
Side Effects:
Side effects include- nausea and different gi disturbances, headache, dizziness, joint pain, and skin rashes.
Pregnancy & Lactation:
There don't seem to be adequate and well-controlled studies in pregnant ladies. Cipro ought to be used throughout gestation as long because the potential profit justifies the potential risk to the vertebrate and mother. Cipro is excreted in human milk. because of the potential risk of articulary injury, Cipro should not be used throughout lactation.
Precautions & Warnings:
Patients receiving Cipro ought to be schooled to drink fluids munificently. It ought to be used with caution in patients with suspected or famous system disorders like encephalopathy or different factors that incline to seizures and convulsion. Avoid in patients with famous QT prolongation, symptoms.
Use in Special Populations:
Although effective in clinical trials, Cipro is not a drug of initial alternative in the pediatric population.
Overdose :
Overdose following Cipro administration might cause seizures, hallucinations, confusion, abdominal discomfort, urinary organ, and viscus impairment conjointly as crystalluria, haematuria, & reversible urinary organ toxicity.
Storage:
Keep below 30°C temperature, protected from lightweight & wetness. exclude of the reach of kids.
Brand Names
Brand Name | Company | Strength |
| Aprocin | Aristopharma Ltd. | 250 mg+500 mg+750 mg |
| Neofloxin | Beximco Pharmaceuticals Ltd. | 250 mg+500 mg+750 mg |
| Beuflox | Incepta Pharmaceuticals Ltd. | 250 mg+500 mg+750 mg |
| Ciprocin | Square Pharmaceuticals Ltd. | 250 mg+500 mg+750 mg |
| Ciprox | Opsonin Pharma Ltd. | 250 mg+500 mg+750 mg |
| Civox | Popular Pharmaceuticals Ltd. | 1250 mg+500 mg+750 mg |